Water → HCID 178511480, 화합물

HRID 26158

반응식

HRID 26158 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][C:12]#[N:13])(=O)=[O:9])=[CH:4][CH:3]=1.[ClH:14].[NH2:15][OH:16].[OH2:17].C([O-])([O-])=O.[Na+].[Na+]>C(O)C>[Cl:14][C:2]1[CH:3]=[CH:4][C:5]([S:8]([CH2:11][C:12](=[NH:13])[NH:15][OH:16])(=[O:9])=[O:17])=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 7358292-(4-Chlorobenzenesulfonyl)acetonitrile

생성물 1

HCID 178511480HCID 178511480, 화합물수율 70%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

50 g. (0.23 mole) of 4-chlorophenylsulfonylacetonitrile were dissolved in 1.5 liters of ethanol and 16 g. (0.23 mole) of hydroxylamine HCl in 150 ml. of water was added to this solution, followed by the addition of 14.4 g. (0.12 mole) of Na2CO3 in 150 ml. of water. This reaction mixture was stirred at room temperature overnight. 58 g. crude product were filtered off; this was recrystallized from about 2.5 liters of ethanol to give 40 g. of the product (70% yield).

후처리

  1. additionfollowed by the addition of 14.4 g
  2. filtrationcrude product were filtered off
  3. customthis was recrystallized from about 2.5 liters of ethanol
  4. customto give 40 g

출처 및 근거

ORD 기록
ord-cfb04106ce044c1b82b83425a88a2633
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04148801

연결된 노트

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