Acetonitrile → (4-Carboxybutyl)triphenylphosphonium bromide

HRID 261916

반응식

HRID 261916 반응식
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7].[C:9]1([P:15]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(#N)C>C1C=CC=CC=1>[Br-:1].[C:6]([CH2:5][CH2:4][CH2:3][CH2:2][P+:15]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)([OH:8])=[O:7]

참가 물질

5

반응물 3

HCID 6342AcetonitrileHCID 11776TriphenylphosphineHCID 163685-Bromovaleric acid

생성물 1

HCID 161236(4-Carboxybutyl)triphenylphosphonium bromide

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A mixture of 103 g. of 5-bromovaleric acid and 152 g. of triphenylphosphine in 400 ml. of acetonitrile is refluxed for 48 hours, cooled, diluted with 100 ml. of benzene and allowed to crystallize. The crystals are filtered, washed with benzene and ether, to yield colorless material, m.p. 207°-209° C.

후처리

  1. additionA mixture of 103 g
  2. temperaturecooled
  3. additiondiluted with 100 ml
  4. customto crystallize
  5. filtrationThe crystals are filtered
  6. washwashed with benzene and ether
  7. customto yield colorless material, m.p. 207°-209° C.

출처 및 근거

ORD 기록
ord-ac6a772fb3ad443cbafbec131e02d7b2
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04152524

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