Ammonia → (4-bromophenyl)(1H-imidazol-2-yl)phenylmethanol

HRID 261931

반응식

HRID 261931 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([C:10]2[N:11](S(C3C=CC(C)=CC=3)(=O)=O)[CH:12]=[CH:13][N:14]=2)[OH:9])=[CH:4][CH:3]=1.Cl.N>O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)([C:10]2[NH:14][CH:13]=[CH:12][N:11]=2)[OH:9])=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 11838798alpha-(p-Bromophenyl)-alpha-phenyl-1-(toluene-p-sulphonyl)imidazole-2-methanol

생성물 1

HCID 12433864(4-bromophenyl)(1H-imidazol-2-yl)phenylmethanol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 24.8 g. (0.052 mol) of α-(p-bromophenyl)-α-phenyl-1-(toluene-p-sulphonyl)imidazole-2-methanol, 160 ml. of 2 N hydrochloric acid solution (0.156 mol) and about 500 ml. of water was boiled under reflux for 5 hours. After cooling the mixture was made alkaline by addition of ammonia. The precipitated solid was collected, treated with activated carbon in boiling toluene and crystallised from toluene. Melting point of the product was 156°-158° C.

후처리

  1. additionA mixture of 24.8 g
  2. temperatureunder reflux for 5 hours
  3. temperatureAfter cooling the mixture
  4. customThe precipitated solid was collected
  5. additiontreated with activated carbon
  6. customcrystallised from toluene
  7. customwas 156°-158° C.

출처 및 근거

ORD 기록
ord-26d17c2475ad44a4a697a698d7e18002
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04152441

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