Water → N-acetyl-3-phenylindoline

HRID 262291노트

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HRID 262291 반응식
[C:1]1([CH:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[OH-].[Na+].[C:19](OC(=O)C)(=[O:21])[CH3:20]>>[C:19]([N:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8]1)(=[O:21])[CH3:20]

참가 물질

5

반응물 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 14798Sodium HydroxideHCID 109323533-phenyl-2,3-dihydro-1H-indole

생성물 1

HCID 15428722N-acetyl-3-phenylindoline

실험 절차

1.0 G of 3-phenylindoline was dissolved in 10 ml of acetic anhydride at room temperature. After 10 minutes, the reaction mixture was poured into 100 ml of water, slightly basified with aqueous sodium hydroxide and extracted with methylene chloride. After removal of the methylenechloride, the residue was recrystallized from cyclohexane to give 1.15 g of the desired N-acetyl-3-phenylindoline which was found to have a 106°-7° C.

후처리

  1. extractionextracted with methylene chloride
  2. customAfter removal of the methylenechloride
  3. customthe residue was recrystallized from cyclohexane

출처 및 근거

ORD 기록
ord-fd9bb74308fb497badfb14f6bc31f721
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04153789

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