Hydrazine hydrate (1:1) → 2-[(4-Methylpiperazin-1-yl)methyl]aniline

HRID 262328

반응식

HRID 262328 반응식
O.NN.[CH3:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-])=O)[CH2:7][CH2:6]1>C(O)C.[Ni]>[CH3:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[NH2:18])[CH2:7][CH2:6]1

참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 7913741-Methyl-4-(2-nitrobenzyl)piperazine

생성물 1

HCID 64845562-[(4-Methylpiperazin-1-yl)methyl]aniline

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

In 30 volume parts of ethanol is dissolved 1.87 parts of N1 -methyl-N4 -(2-nitrobenzyl)piperazine, followed by the addition of 3.0 parts of Raney nickel. Then, 3.0 parts of hydrazine hydrate is further added to the mixture and the entire mixture is kept at room temperature for 2 hours. Following this reaction, the Raney nickel is filtered off and the solvent is distilled off under reduced pressure. The residual oily substance is recrystallized from aqueous methanol. The procedure gives pale yellow crystals melting at 78° to 79° C.

후처리

  1. customthis reaction
  2. filtrationthe Raney nickel is filtered off
  3. distillationthe solvent is distilled off under reduced pressure
  4. customThe residual oily substance is recrystallized from aqueous methanol

출처 및 근거

ORD 기록
ord-95c8fb53c13d473a95aa0562f28fc929
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04153794

연결된 노트

불러오는 중…