Cysteamine Hydrochloride → 2-(3-Bromo-4-methyl-2-pyridylmethylthio)ethylamine dihydrobromide

HRID 262512노트

반응식

HRID 262512 반응식
[Br:1][C:2]1[C:3]([CH2:9]O)=[N:4][CH:5]=[CH:6][C:7]=1[CH3:8].Cl.[NH2:12][CH2:13][CH2:14][SH:15]>Br>[BrH:1].[BrH:1].[Br:1][C:2]1[C:3]([CH2:9][S:15][CH2:14][CH2:13][NH2:12])=[N:4][CH:5]=[CH:6][C:7]=1[CH3:8]

참가 물질

4

반응물 2

HCID 9082Cysteamine HydrochlorideHCID 23344241(3-Bromo-4-methylpyridin-2-yl)methanol

생성물 1

HCID 233492852-(3-Bromo-4-methyl-2-pyridylmethylthio)ethylamine dihydrobromide

시약·촉매·용매 1

HCID 260Hydrogen Bromide용매

실험 절차

A mixture of 3-bromo-2-hydroxymethyl-4-methylpyridine (5.8), cysteamine hydrochloride (3.5 g) and hydrobromic acid (48%, 50 ml) was refluxed for 6 hours and evaporated to dryness. The residue was crystallised from isopropanol/methanol to give 2-(3-bromo-4-methyl-2-pyridylmethylthio)ethylamine dihydrobromide (8.5 g) m.p. 203°-205°.

후처리

  1. temperaturewas refluxed for 6 hours
  2. customevaporated to dryness
  3. customThe residue was crystallised from isopropanol/methanol

출처 및 근거

ORD 기록
ord-16bd9088e36c4f93afd23493c17c62b2
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04154834

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