Ethyl formate → Ethyl 2-(hydroxymethyl)-3-(3-pyridyl)butyrate

HRID 262518노트

반응식

HRID 262518 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([CH3:14])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:2]=1.[CH:15](OCC)=[O:16].[H-].[Na+]>C(COC)OC>[OH:16][CH2:15][CH:8]([CH:7]([C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10]

참가 물질

5

반응물 3

HCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 12727116Ethyl 3-(pyridin-3-yl)butanoate

생성물 1

HCID 23349231Ethyl 2-(hydroxymethyl)-3-(3-pyridyl)butyrate

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

Treatment of ethyl 3-(3-pyridyl)butyrate with ethyl formate and sodium hydride in glyme, followed by acidification gave ethyl 2-(hydroxymethyl)-3-(3-pyridyl)butyrate, m.p. 128°-131°.

출처 및 근거

ORD 기록
ord-7ac13fcb344947da8d068eb15cffe5d7
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04154834

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