Cysteamine Hydrochloride → 2-(2-Aminoethylthiomethyl)-3-ethoxypyridine

HRID 263242

반응식

HRID 263242 반응식
Cl.[NH2:2][CH2:3][CH2:4][SH:5].[Na].Cl.Cl[CH2:9][C:10]1[C:15]([O:16][CH2:17][CH3:18])=[CH:14][CH:13]=[CH:12][N:11]=1>C(O)C>[NH2:2][CH2:3][CH2:4][S:5][CH2:9][C:10]1[C:15]([O:16][CH2:17][CH3:18])=[CH:14][CH:13]=[CH:12][N:11]=1

참가 물질

5

반응물 3

HCID 9082Cysteamine HydrochlorideHCID 5360545SodiumHCID 204741852-Chloromethyl-3-ethoxypyridine hydrochloride

생성물 1

HCID 204022362-(2-Aminoethylthiomethyl)-3-ethoxypyridine수율 89.5%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Cysteamine hydrochloride (2.76 g) was added to a stirred mixture of sodium (1.576 g) in ethanol (75 cc) at 12°, 2-Chloromethyl-3-ethoxypyridine hydrochloride (4.60 g) in ethanol (70 cc) was added over 30 minutes to this mixture stirred at 10°-12°. The mixture was left to stand overnight, filtered and the filtrate was evaporated to dryness. The residue was dissolved in water, acidified to pH4 with hydrochloric acid and extracted with chloroform (discarded). The aqueous phase was adjusted to pH 12 with aqueous sodium hydroxide and was extracted with chloroform. The chloroform extracts were evaporated to give 2-(2-aminoethylthiomethyl)-3-ethoxypyridine (4.2 g) ad an oil.

후처리

  1. waitThe mixture was left
  2. filtrationfiltered
  3. customthe filtrate was evaporated to dryness
  4. dissolutionThe residue was dissolved in water
  5. extractionextracted with chloroform (discarded)
  6. extractionwas extracted with chloroform
  7. customThe chloroform extracts were evaporated

출처 및 근거

ORD 기록
ord-cca4dcb9136a473aaa5ff84cb8585014
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04156727

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