3-Pyridinemethanol → O-[(Pyridin-3-yl)methyl] (4-cyanophenyl)carbamothioate

HRID 263303

반응식

HRID 263303 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][OH:8])[CH:2]=1.[H-].[Na+].[C:11]([C:13]1[CH:18]=[CH:17][C:16]([N:19]=[C:20]=[S:21])=[CH:15][CH:14]=1)#[N:12].C(=O)(O)[O-].[Na+].NC(N)=S>O.C(COC)OC>[C:11]([C:13]1[CH:14]=[CH:15][C:16]([NH:19][C:20](=[S:21])[O:8][CH2:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)=[CH:17][CH:18]=1)#[N:12]

참가 물질

8

반응물 5

HCID 75103-PyridinemethanolHCID 17626Benzonitrile, 4-isothiocyanato-HCID 24758Sodium hydrideHCID 516892Sodium BicarbonateHCID 2723790Thiourea

생성물 1

HCID 12790266O-[(Pyridin-3-yl)methyl] (4-cyanophenyl)carbamothioate수율 43.5%

시약·촉매·용매 2

HCID 962Water용매HCID 80711,2-Dimethoxyethane용매2회

실험 절차

To a solution of 3-pyridylcarbinol (2.18g., 0.02 mole) in 50 ml. of glyme there is added sodium hydride (0.87g. of a 57% oil dispersion, 0.02 mole). The solution is allowed to stand 2 hrs. and then p-cyanophenyl isothiocyanate (3.2g., 0.02 mole) in 50 ml. of glyme is added dropwise. The reaction mixture is stirred at room temperature for 18 hrs. It is then saturated with sodium bicarbonate and poured into an excess of water. The resulting suspension is filtered to give a solid residue which is recrystallized from toluene to give 2.3g. of solid melting at 153°-154° C., with decomposition. The thiourea structure is confirmed by infra-red spectroscopy. The product is obtained in a 43.5% yield.

후처리

  1. filtrationThe resulting suspension is filtered
  2. customto give a solid residue which
  3. customis recrystallized from toluene
  4. customto give 2.3g
  5. customThe product is obtained in a 43.5% yield

출처 및 근거

ORD 기록
ord-a466d27218384f8aa65905f1c4d56569
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04156780

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