Phthalic Anhydride → 2-(8-Chloro-2-methylquinolin-5-yl)-1H-isoindole-1,3(2H)-dione

HRID 26364

반응식

HRID 26364 반응식
ClC1C(Cl)=C(Cl)C=CC=1.[Cl:10][C:11]1[CH:12]=[CH:13][C:14]([NH2:22])=[C:15]2[C:20]=1[N:19]=[C:18]([CH3:21])[CH:17]=[CH:16]2.[C:23]1(=O)[O:28][C:26](=[O:27])[C:25]2=[CH:29][CH:30]=[CH:31][CH:32]=[C:24]12>>[Cl:10][C:11]1[CH:12]=[CH:13][C:14]([N:22]2[C:26](=[O:27])[C:25]3=[CH:29][CH:30]=[CH:31][CH:32]=[C:24]3[C:23]2=[O:28])=[C:15]2[C:20]=1[N:19]=[C:18]([CH3:21])[CH:17]=[CH:16]2

참가 물질

4

반응물 3

HCID 6811Phthalic AnhydrideHCID 68951,2,3-TrichlorobenzeneHCID 213229278-Chloro-2-methylquinolin-5-amine

생성물 1

HCID 213229162-(8-Chloro-2-methylquinolin-5-yl)-1H-isoindole-1,3(2H)-dione수율 83.3%

실험 절차

95 g of trichlorobenzene was added to 23.3 g (0.12 mole) of 8-chloro-5-amino-quinaldine and 18.0 g (0.12 mole) of phthalic anhydride, and the mixture was reacted under reflux for 2 hours at the boiling point. After cooling, the precipitated crystals were separated by filtration, and dried to afford 32 g (0.10 mole) of 8-chloro-5-phthalimidoquinaldine.

후처리

  1. customthe mixture was reacted
  2. temperatureunder reflux for 2 hours at the boiling point
  3. temperatureAfter cooling
  4. customthe precipitated crystals were separated by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-6b48f7d1232f46a9947bdd586f8143d2
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04150025

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