Hydrochloric Acid → 7-Oxo-9-methoxy-7H-furo[3,2-g][1]benzopyran-6-carboxylic acid

HRID 26375

반응식

HRID 26375 반응식
[OH:1][C:2]1[C:10]([CH:11]=O)=[CH:9][C:5]2[CH:6]=[CH:7][O:8][C:4]=2[C:3]=1[O:13][CH3:14].[C:15]([CH2:17][C:18]([O:20]CC)=[O:19])#N.[OH-:23].[Na+].Cl>O>[O:23]=[C:15]1[C:17]([C:18]([OH:20])=[O:19])=[CH:11][C:10]2[CH:9]=[C:5]3[CH:6]=[CH:7][O:8][C:4]3=[C:3]([O:13][CH3:14])[C:2]=2[O:1]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7764Ethyl cyanoacetateHCID 14798Sodium HydroxideHCID 217856846-Hydroxy-7-methoxy-5-benzofurancarboxaldehyde

생성물 1

HCID 217856857-Oxo-9-methoxy-7H-furo[3,2-g][1]benzopyran-6-carboxylic acid

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

The aldehyde of Example 5 (192 mg., 1 mmole) in 1 ml. of water was added to a solution of ethyl cyanoacetate (125 mg., 1.1 mmole) in 1 ml. of water containing 200 mg. of sodium hydroxide. The mixture was stirred at room temperature for 20 hours then treated with 8 ml. of 2N HCl under reflux for 30 minutes. After cooling, the product was isolated by centrifugation followed by crystallization from ethanol to yield a yellow solid, m.p. 227°-228°.

후처리

  1. additionthen treated with 8 ml
  2. temperatureAfter cooling
  3. customthe product was isolated by centrifugation
  4. customfollowed by crystallization from ethanol
  5. customto yield a yellow solid, m.p. 227°-228°

출처 및 근거

ORD 기록
ord-5a981ebacd3c470394ccc010da8f719e
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04150042

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