4-Methoxybenzenesulfonyl chloride → N-benzyl-4-methoxybenzenesulfonamide

HRID 264311

반응식

HRID 264311 반응식
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([S:17](Cl)(=[O:19])=[O:18])=[CH:13][CH:12]=1>C(Cl)(Cl)Cl>[CH3:9][O:10][C:11]1[CH:12]=[CH:13][C:14]([S:17]([NH:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)(=[O:19])=[O:18])=[CH:15][CH:16]=1

참가 물질

4

반응물 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 7504Benzylamine

생성물 1

HCID 741351N-benzyl-4-methoxybenzenesulfonamide

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
0 °C

실험 절차

Benzylamine (16.0 mL, 145.2 mmol) is dissolved in chloroform (110 mL), and the solution is cooled to 0° C. To this solution is added 4-methoxybenzenesulfonyl chloride (10.0 g, 48.4 mmol). The reaction is stirred at room temperature for 1 hour, and then refluxed for 1 hour. After cooling back to room temperature, the reaction is washed three times with 4N hydrochloric acid (200 mL), twice with water (100 mL), once with brine (50 mL), then dried (Na2SO4), and the solvent is evaporated to give N-[4-methoxybenzenesulfonyl]-benzylamine.

후처리

  1. temperaturerefluxed for 1 hour
  2. temperatureAfter cooling back to room temperature
  3. washthe reaction is washed three times with 4N hydrochloric acid (200 mL)
  4. dry with materialtwice with water (100 mL), once with brine (50 mL), then dried (Na2SO4)
  5. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-480680a942d14e20afb3ab5e47cdfdb3
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646167

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