Water → 2-(p-Isobutylphenyl)propionic acid benzyl ester

HRID 26449

반응식

HRID 26449 반응식
[Na+].[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([CH:12]([CH3:16])[C:13]([O-:15])=[O:14])=[CH:8][CH:7]=1)[CH:3]([CH3:5])[CH3:4].[CH2:17](Cl)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.O>CN(C)C=O>[CH2:17]([O:14][C:13](=[O:15])[CH:12]([C:9]1[CH:8]=[CH:7][C:6]([CH2:2][CH:3]([CH3:5])[CH3:4])=[CH:11][CH:10]=1)[CH3:16])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 7503Benzyl ChlorideHCID 5338317Ibuprofen, Sodium Salt

생성물 1

HCID 104246622-(p-Isobutylphenyl)propionic acid benzyl ester수율 86.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
90 °C

실험 절차

To a mixture of 2.28 g of 2-(p-isobutylphenyl)propionic acid sodium salt in 20 ml of dimethylformamide was added 2.52 g of benzyl chloride and the whole was heated at 90° C. for 3 hours. After the reaction was complete, the solvent was removed by distillation under reduced pressure to leave a residue, to which was added water. The resulting mixture was extracted with ether and the extract was dehydrated. The ether was removed by distillation to give an oily product. Distillation of this product under reduced pressure yielded 2.57 g of 2-(p-isobutylphenyl)propionic acid benzyl ester as a colorless oil, boiling at 108°-110° C./0.1 mmHg. Analysis-Calculated for C20H24O2 : C, 81.04; H, 8.16. Found: C, 80.92; H, 8.02.

후처리

  1. customthe solvent was removed by distillation under reduced pressure
  2. customto leave a residue
  3. extractionThe resulting mixture was extracted with ether
  4. customThe ether was removed by distillation
  5. customto give an oily product
  6. distillationDistillation of this product under reduced pressure

출처 및 근거

ORD 기록
ord-4f232384f543447b942e3eaf5c6ef308
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04150137

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