Hydrochloric Acid → (2,5-Dichlorophenyl)(3-methylphenyl)methanone

HRID 264593

반응식

HRID 264593 반응식
[C:1]1([CH3:10])[CH:6]=[CH:5][CH:4]=[C:3]([C:7](Cl)=[O:8])[CH:2]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1.[Cl-].[Al+3].[Cl-].[Cl-].Cl>CCOCC>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=1[C:7]([C:3]1[CH:4]=[CH:5][CH:6]=[C:1]([CH3:10])[CH:2]=1)=[O:8]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 46851,4-DichlorobenzeneHCID 743753-Methylbenzoyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 18704036(2,5-Dichlorophenyl)(3-methylphenyl)methanone수율 53%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
100 °C

실험 절차

A mixture of m-toluoyl chloride (22 g, 0.17 mol) and 1,4-dichlorobenzene (120 g, 0.82 mol) was heated to 100° C. in a flask. Aluminum chloride (60 g, 0.45 mol) was added in one portion. Hydrogen chloride started to evolve from the solution. The mixture was heated to 170° C. in 30 min. and stirred at this temperature for 3 hours. The resulting brownish solution was cooled to about 80° C. and poured onto ice. Ether (50 ml) was added. The organic layer was separated and distilled under vacuum after the removal of ether. The residue from distillation was recrystallized twice from hexane to give 20 g of white crystals (53%).

후처리

  1. temperatureThe mixture was heated to 170° C. in 30 min.
  2. temperatureThe resulting brownish solution was cooled to about 80° C.
  3. additionpoured onto ice
  4. customThe organic layer was separated
  5. distillationdistilled under vacuum
  6. customafter the removal of ether
  7. distillationThe residue from distillation
  8. customwas recrystallized twice from hexane

출처 및 근거

ORD 기록
ord-e1e398b434e24d5baa04bd4993df5455
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646231

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