Ethyl Acrylate → Ethyl (3-benzyloxy-6-hydroxymethylpyridin-2-yl)propenoate

HRID 264789

반응식

HRID 264789 반응식
[CH2:1]([O:8][C:9]1[C:10](I)=[N:11][C:12]([CH2:15][OH:16])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O-])(=O)C.[K+].[C:23]([O:27][CH2:28][CH3:29])(=[O:26])[CH:24]=[CH2:25]>CN(C=O)C.O>[CH2:1]([O:8][C:9]1[C:10]([C:24](=[CH2:25])[C:23]([O:27][CH2:28][CH3:29])=[O:26])=[N:11][C:12]([CH2:15][OH:16])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 8821Ethyl AcrylateHCID 517044Potassium AcetateHCID 196927123-Benzyloxy-6-hydroxymethyl-2-iodopyridine

생성물 1

HCID 86751041Ethyl (3-benzyloxy-6-hydroxymethylpyridin-2-yl)propenoate수율 62%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
120 °C

실험 절차

To a solution of 3-benzyloxy-6-hydroxymethyl-2-iodopyridine (1.20 g, 3.50 mmol) in DMF (6.4 ml) and water (0.32 ml) were added potassium acetate (0.83 g, 8.5 mmol) palladium acetate (32 mg, 0.14 mmol) and ethyl acrylate (1.1ml, 1.01 g, 10 mmol). The mixture was placed under nitrogen and stirred and heated at 120° C. for 1.25 h. By hplc the solution yield was 62%.

출처 및 근거

ORD 기록
ord-3b9686b7cdd04c39bcff3ecc3658d90a
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646286

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