Sodium Hydroxide → 4-(4-Chlorobutyloxy)benzoic acid

HRID 265892노트

반응식

HRID 265892 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][CH:8]=1.[OH-].[Na+].OS([O-])(=O)=O.[K+]>C(O)C>[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([C:11]([OH:13])=[O:12])=[CH:15][CH:16]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 516920Potassium bisulfateHCID 14575308Methyl 4-(4-chlorobutoxy)benzoate

생성물 1

HCID 190341754-(4-Chlorobutyloxy)benzoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

A mixture of 24-2 (3.0 g, 12.4 mmol), 1N NaOH (30 mL), and ethanol was heated at 60° C. for 1.0 hour. The cooled reaction mixture was acidified with 10% KHSO4 and then extracted with EtOAc. The EtOAc portion was washed with brine, dried (MgSO4) and concentrated to give 24-3 as a white solid.

후처리

  1. customThe cooled reaction mixture
  2. extractionextracted with EtOAc
  3. washThe EtOAc portion was washed with brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-21803ed5b24647c39e159b4ca30aa559
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05648368

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