Hydrochloric Acid → 4-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoic acid

HRID 265896노트

반응식

HRID 265896 반응식
[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][O:15][C:16]2[CH:25]=[CH:24][C:19]([C:20]([O:22]C)=[O:21])=[CH:18][CH:17]=2)[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][O:15][C:16]2[CH:17]=[CH:18][C:19]([C:20]([OH:22])=[O:21])=[CH:24][CH:25]=2)[N:10]=[CH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18928610Methyl 4-[2-(1-Benzylimidazol-4-yl)ethyloxy]benzoate

생성물 1

HCID 158507574-[2-(N-Benzylimidazol-4-yl)ethyloxy]benzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of the ester 25-4 (170 mg, 0.51 mmol), CH3OH (10 mL), and 1N NaOH (5 mL) was stirred for 20 hours at ambient temperature. The cooled reaction mixture was acidified with 1N HCl (5 mL) and extracted with EtOAc. The EtOAc portion was concentrated to give 25-5 as a gelataneous solid.

후처리

  1. customThe cooled reaction mixture
  2. extractionextracted with EtOAc
  3. concentrationThe EtOAc portion was concentrated

출처 및 근거

ORD 기록
ord-706bd961279a411c84650ee391878fb9
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05648368

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