Ethanethiol → HCID 67596278, 화합물

HRID 266491

반응식

HRID 266491 반응식
[C:1]1([N:7]2[C:11]([S:12][CH2:13][N:14]3[C:24](=[O:25])[C:23]4[C:18](=[CH:19][C:20]([O:31][CH3:32])=[C:21]([O:29]C)[C:22]=4[CH:26]([CH3:28])[CH3:27])[S:15]3(=[O:17])=[O:16])=[N:10][N:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl-].[Al+3].[Cl-].[Cl-].C(S)C.C(OCC)(=O)C.CCCCCC>C(Cl)(Cl)Cl>[C:1]1([N:7]2[C:11]([S:12][CH2:13][N:14]3[C:24](=[O:25])[C:23]4[C:18](=[CH:19][C:20]([O:31][CH3:32])=[C:21]([OH:29])[C:22]=4[CH:26]([CH3:27])[CH3:28])[S:15]3(=[O:16])=[O:17])=[N:10][N:9]=[N:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 4

HCID 6343EthanethiolHCID 6451240Aluminum(III) ChlorideHCID 21226206Ethyl acetate hexaneHCID 443413782-(1-Phenyltetrazol-5-yl)thiomethyl-4-isopropyl-5,6-dimethoxy-saccharin

생성물 1

HCID 67596278HCID 67596278, 화합물수율 77%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

2-(1-phenyltetrazol-5-yl)thiomethyl-4-isopropyl-5,6-dimethoxy-saccharin (0.48 g) was added with stirring at 0° C. to a solution of aluminum chloride (0.4 g) and ethanethiol (0.15 mL) in chloroform (3 mL). The temperature was allowed to rise to and remain at room temperature for 18 hours. The reaction mixture was passed through silica gel with ethyl acetate-hexane (2:3) as eluant affording as a colorless oil 2-(1-phenyltetrazol-5-yl)thiomethyl-4-isopropyl-5-hydroxy-6-methoxy-saccharin, 0.3 g, 77% yield, whose structure was proven by proton and carbon-13 magnetic resonance, mass spectrometric and nuclear Overhauser enhancement analyses. The latter analysis showed 19% enhancement of the methoxy protons signal and 10% enhancement of the C-7 proton signal.

출처 및 근거

ORD 기록
ord-ae3e2977941043129530b19f70808fec
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05650422

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