Ethyl orthoformate → 5-Methyl-1-[alpha-(o-chlorophenyl)-o-tolyl]imidazole

HRID 267284노트

반응식

HRID 267284 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]1[C:10](=[CH:12][CH:13]=[CH:14][CH:15]=1)[NH2:11].[CH:16](OCC)(OCC)OCC.[CH3:26][C:27]1([CH2:32][NH2:33])OCCO1>[Ti](Cl)(Cl)(Cl)Cl>[CH3:26][C:27]1[N:11]([C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[CH2:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[CH:16]=[N:33][CH:32]=1

참가 물질

5

반응물 3

HCID 31214Ethyl orthoformateHCID 12434663(2-Methyl-1,3-dioxolan-2-yl)methanamineHCID 134266642-[(2-Chlorophenyl)methyl]aniline

생성물 1

HCID 214973875-Methyl-1-[alpha-(o-chlorophenyl)-o-tolyl]imidazole

시약·촉매·용매 1

HCID 24193Titanium Tetrachloride촉매

실험 절차

In the manner given in Example 3, α-(0-chlorophenyl)-0-toluidine is reacted with triethyl orthoformate, the resulting oil is heated with 2-methyl-2-(aminomethyl)-1,3-dioxolane, and the resulting product treated with titanium tetrachloride to give 5-methyl-1-[α-(0-chlorophenyl)-0-tolyl]imidazole.

출처 및 근거

ORD 기록
ord-34e25510f4724abf9cc493908612ca66
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03941802

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