Ethyl orthoformate → 5-Methyl-1-(alpha-phenyl-o-tolyl)imidazole

HRID 267417

반응식

HRID 267417 반응식
[C:1]1([CH2:7][C:8]2[C:9](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:15](OCC)(OCC)OCC.[CH3:25][C:26]1([CH2:31][NH2:32])OCCO1>[Ti](Cl)(Cl)(Cl)Cl>[CH3:25][C:26]1[N:10]([C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:15]=[N:32][CH:31]=1

참가 물질

5

반응물 3

HCID 31214Ethyl orthoformateHCID 1198052-BenzylanilineHCID 12434663(2-Methyl-1,3-dioxolan-2-yl)methanamine

생성물 1

HCID 214973675-Methyl-1-(alpha-phenyl-o-tolyl)imidazole

시약·촉매·용매 1

HCID 24193Titanium Tetrachloride촉매

실험 절차

In the manner given in Preparation 23, α-phenyl-o-toluidine is reacted with triethyl orthoformate, the resulting oil is heated with 2-methyl-2-(aminomethyl)-1,3-dioxolane, and the resulting product treated with titanium tetrachloride to give 5-methyl-1-(α-phenyl-o-tolyl)imidazole.

출처 및 근거

ORD 기록
ord-d1143b38c60c4a2aa7090292628ed2d4
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03941803

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