Aluminum(III) Chloride → 5-Fluoro-2-methylindan-1-one

HRID 267825노트

반응식

HRID 267825 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:12])[C:9]([CH3:11])=[CH2:10])=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-]>C(=S)=S>[F:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[C:8](=[O:12])[CH:9]([CH3:11])[CH2:10]2

참가 물질

4

반응물 2

HCID 6451240Aluminum(III) ChlorideHCID 132782011-(4-Fluorophenyl)-2-methylprop-2-en-1-one

생성물 1

HCID 30162575-Fluoro-2-methylindan-1-one

시약·촉매·용매 1

HCID 6348Carbon Disulfide용매

반응 조건

온도
45 °C

실험 절차

Fifty grams (0.30 moles) of 4'-fluoro-2-methylacrylophenone is added to a slurry of 60.1 g. (0.45 moles) of anhydrous aluminum chloride in 27 ml. of carbon disulfide at 20°-25°C over one hour. The mixture is heated to 45°C over one hour and stirred at 45°C for one hour. The reaction is quenched in ice. The oily aqueous layer is extracted with toluene. The toluene layer is washed with aqueous sodium hydroxide and water and concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

후처리

  1. customThe reaction is quenched in ice
  2. extractionThe oily aqueous layer is extracted with toluene
  3. washThe toluene layer is washed with aqueous sodium hydroxide and water
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-1ff83bf6febf4d849c5a367efe41df33
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03944600

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