Hydrogen Bromide → 2-Bromo-4-trifluoromethylaniline

HRID 267969

반응식

HRID 267969 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=1.[Br:12]Br.Br>[Fe]>[Br:12][C:3]1[CH:4]=[C:5]([C:8]([F:9])([F:10])[F:11])[CH:6]=[CH:7][C:2]=1[NH2:1]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 99644-(Trifluoromethyl)anilineHCID 24408Bromine

생성물 1

HCID 938992-Bromo-4-trifluoromethylaniline

시약·촉매·용매 1

HCID 23925Iron촉매

실험 절차

To 161.0 g of p-aminobenzotrifluoride and 10.0 g of iron filings is added, dropwise, with agitation at 35°-40°, 160.0 g of bromine, using a slow stream of nitrogen to sweep out the evolved hydrogen bromide. Subsequently, the mixture is agitated for an additional two hours and then distilled in vacuo to give 3-bromo-4-aminobenzotrifluoride.

후처리

  1. customat 35°-40°
  2. distillationdistilled in vacuo

출처 및 근거

ORD 기록
ord-43f19edd3f3340d590cf99d0d5f9b7f4
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03946025

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