Water → HCID 53900511, 화합물

HRID 268391노트

반응식

HRID 268391 반응식
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([CH2:10][CH3:11])[C:7]([OH:12])=[C:6]([CH2:13][CH3:14])[CH:5]=1.[OH-].[Na+].O.S(OC)(O[CH3:23])(=O)=O>CCOCC>[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([CH2:10][CH3:11])[C:7]([O:12][CH3:23])=[C:6]([CH2:13][CH3:14])[CH:5]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6497Dimethyl SulfateHCID 14798Sodium HydroxideHCID 541130503,5-Diethyl-4-hydroxybenzoic acid methyl ester

생성물 1

HCID 53900511HCID 53900511, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a cooled solution of 16.2 g. (0.078 mol.) of 3,5-diethyl-4-hydroxybenzoic acid methyl ester and 4.0 g. (0.1 mol.) of sodium hydroxide in 100 ml. of water is added 9.8 g. (7.3 ml., 0.079 mol.) of dimethyl sulfate. The reaction mixture is refluxed for 2 hours. After cooling, ether is added and the layers are separated. The organic phase is washed with water, dilute sulfuric acid and water, dried (Na2SO4) and concentrated to give 3,5-diethyl-4-methoxybenzoic acid methyl ester.

후처리

  1. temperatureThe reaction mixture is refluxed for 2 hours
  2. temperatureAfter cooling
  3. customthe layers are separated
  4. washThe organic phase is washed with water, dilute sulfuric acid and water
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f9fa7b4dbd8b424b97fef61656888c76
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03947470

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