Dibenzoylmethane → Tribenzoylmethane

HRID 268507

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HRID 268507 반응식
[C:1]([O:7]CC)(=O)[CH2:2][C:3]([CH3:5])=[O:4].[C:10]([CH:15]1[CH2:19][CH2:18][CH2:17][C:16]1=[O:20])(OCC)=O.C[CH:22]([C:26](=O)[CH3:27])[C:23](=O)[CH3:24].[C:29](F)(=O)C.[C:33]([CH:36]([C:42]([CH3:44])=O)C(OCC)=O)(=O)[CH3:34].[C:45]([C:48]1([C:54](OCC)=O)[CH2:52][CH2:51][CH2:50][C:49]1=O)(=[O:47])[CH3:46].C(C(C)(C(=O)C)C(=O)C)(=O)C.C(CC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.C(F)(=O)C1C=CC=CC=1>>[C:16]([CH:2]([C:1](=[O:7])[C:49]1[CH:50]=[CH:51][CH:52]=[CH:48][CH:54]=1)[C:3](=[O:4])[C:5]1[CH:27]=[CH:26][CH:22]=[CH:23][CH:24]=1)(=[O:20])[C:15]1[CH:10]=[CH:29][CH:17]=[CH:18][CH:19]=1.[C:45]([CH:2]([C:1](=[O:7])[C:10]1[CH:15]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:3](=[O:4])[C:5]1[CH:44]=[CH:42][CH:36]=[CH:33][CH:34]=1)(=[O:47])[CH3:46]

참가 물질

11

반응물 9

HCID 8433Dibenzoylmethane2회HCID 8868Ethyl AcetoacetateHCID 11204Acetyl fluoride2회HCID 67999Benzoyl fluorideHCID 69136Ethyl 2-oxocyclopentanecarboxylateHCID 699493-Methyl-2,4-pentanedioneHCID 79063Ethyl 2-acetylacetoacetateHCID 121311812,4-Pentanedione, 3-acetyl-3-methyl-HCID 214389482-Acetyl-2-carbethoxycyclopentanone

생성물 2

HCID 413869TribenzoylmethaneHCID 7863132-Benzoyl-1-phenyl-1,3-butanedione

실험 절차

When the thallous salts of ethyl acetoacetate, 2-carbethoxycyclopentanone, and 3-methylpentane-2,4-dione, prepared according to Example 1, are treated with acetyl fluoride at room temperature as described in Example 4, ethyl 2-acetyl-acetoacetate, 2-acetyl-2-carbethoxycyclopentanone, and 3-acetyl-3-methylpentane-2,4-dione, respectively, are obtained in 95% yield. Tribenzoylmethane is prepared by treating the thallous salt of dibenzoylmethane with benzoyl fluoride in the same manner. Acetyldibenzoylmethane is prepared by treating the thallous salt of dibenzoylmethane with acetyl fluoride.

후처리

  1. customrespectively, are obtained in 95% yield

출처 및 근거

ORD 기록
ord-9f27d11f015549b89859d82d99f296af
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03947488

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