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Sodium Hydroxide → 3-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid

HRID 26926
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반응식

HRID 26926 반응식
[OH-:1].[Na+].[F:3][C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([OH:22])([CH3:21])[CH2:18][CH2:19][OH:20])=[CH:13][CH:12]=1>[Ag]=O.[N+]([O-])([O-])=O.[Ag+].O>[F:3][C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([OH:22])([CH3:21])[CH2:18][C:19]([OH:1])=[O:20])=[CH:13][CH:12]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 14798Sodium Hydroxide2회HCID 213225623-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol

생성물 1

HCID 213225833-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid

시약·촉매·용매 3

HCID 24470Silver Nitrate촉매HCID 92152Silver(II) oxide촉매HCID 962Water
용매
2회

실험 절차

Silver oxide, freshly prepared from 3.2 g. of AgNO3 and 0.8 g. of NaOH in 25 ml. of water, is added to a mixture of 2.78 g. of 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol and 2 g. of NaOH in 20 ml. of water. The mixture is heated under reflux for 2 hours and filtered. The filtrate is worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid, m.p. 121°-123°.

후처리

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 2 hours
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-c1d12b4e009b4caea87982793f81e86f
출처 데이터셋
uspto-grants-1979_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04151302

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