Methyl iodide → Metribuzin

HRID 26951

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HRID 26951 반응식
[SH:1][C:2]1[N:7]([NH2:8])[C:6](=[O:9])[C:5]([C:10]([CH3:13])([CH3:12])[CH3:11])=[N:4][N:3]=1.[CH3:14]I>[OH-].[Na+].CO>[CH3:14][S:1][C:2]1[N:7]([NH2:8])[C:6](=[O:9])[C:5]([C:10]([CH3:13])([CH3:12])[CH3:11])=[N:4][N:3]=1

참가 물질

5

반응물 2

HCID 6328Methyl iodideHCID 178441961HCID 178441961, 화합물

생성물 1

HCID 30479Metribuzin수율 82%

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

반응 조건

온도
20 °C

실험 절차

4 parts by weight of 3-mercapto-4-amino-6-tert.-butyl-1,2,4-triazin-5-(4H)-one are dissolved in a mixture of 11 parts by weight of 2 normal sodium hydroxide solution and 4 parts by weight of methanol and the solution is treated at 0° C. with 3.2 parts by weight of methyl iodide. The reaction mixture is then stirred at 20° C. for a further 4 hours. The reaction product crystallizes out, is filtered off, dried and recrystallized from benzene. 3.52 parts by weight of 3-methylthio-4-amino-6-tert.-butyl-1,2,4-triazin-5(4H)-one (XV) of melting point 126°-127° are obtained. Yield: 82% of theory.

후처리

  1. customThe reaction product crystallizes out
  2. filtrationis filtered off
  3. customdried
  4. customrecrystallized from benzene

출처 및 근거

ORD 기록
ord-895559a8b91f4e94b2870734f5b36b91
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04151355

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