Acetic Anhydride → N-(4-fluoro-2-hydroxyphenyl)acetamide

HRID 270055노트

반응식

HRID 270055 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-])=O)=[C:6]([OH:8])[CH:7]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>[Pt].CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:9][C:12](=[O:14])[CH3:13])=[C:6]([OH:8])[CH:7]=1

참가 물질

5

반응물 2

HCID 7918Acetic AnhydrideHCID 99375-Fluoro-2-nitrophenol

생성물 1

HCID 177738N-(4-fluoro-2-hydroxyphenyl)acetamide수율 87.4%

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 887Methanol용매

실험 절차

A mixture of 5-fluoro-2-nitrophenol (5 g, 31.8 mmol), acetic anhydride (4.86 g, 47.7 mmol) and platinum on carbon (5%, 200 mg) in methanol was hydrogenated at 35 psi for 3 hours. The catalyst was filtered off and the residue was purified by silica gel flash chromatography to give the subtitled compound (4.7 g).

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe residue was purified by silica gel flash chromatography

출처 및 근거

ORD 기록
ord-a26a1d68247b4745ab08f78a13da12b9
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449475B2

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