Acetic Anhydride → N-(4-Chloro-2-hydroxyphenyl)acetamide

HRID 270073

반응식

HRID 270073 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].[C:10](OC(=O)C)(=[O:12])[CH3:11]>CO>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:10](=[O:12])[CH3:11])=[C:3]([OH:9])[CH:4]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 915912-Amino-5-chlorophenol

생성물 1

HCID 177739N-(4-Chloro-2-hydroxyphenyl)acetamide수율 91.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a suspension of 2-amino-5-chlorophenol (1.01 g, 7.0 mmol) in methanol (10 mL) was added acetic anhydride (1.08 g, 10.55 mmol) and the reaction mixture was stirred at room temperature for 30 min. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (hexane:ethyl acetate 5:2) to give the subtitled compound (1.19 g).

후처리

  1. customThe volatiles were removed in vacuo
  2. customthe residue was purified by silica gel flash chromatography (hexane:ethyl acetate 5:2)

출처 및 근거

ORD 기록
ord-c24fa62b13a64ab6b70ce5338142fb9d
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449475B2

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