Triphenylphosphine → 3-Methyl-4-methoxybenzyl triphenylphosphonium chloride

HRID 270156

반응식

HRID 270156 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][Cl:10])=[CH:5][C:4]=1[CH3:11].[C:12]1([P:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1(C)C=CC=CC=1>[Cl-:10].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][P+:18]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[CH:5][C:4]=1[CH3:11]

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 1437424-Methoxy-3-methylbenzyl chloride

생성물 1

HCID 461800353-Methyl-4-methoxybenzyl triphenylphosphonium chloride수율 71%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a 250ml round-bottom flask equipped with a magnetic stir-bar and N2inlet was added 4-(Chloromethyl)-2-methylphenyl methyl ether (2.59g, 15.18mmoles, 1eq), dry toluene (50ml, 0.3M) and triphenylphosphine (3.98g, 15.18mmoles, 1eq). The reaction mixture was refluxed overnight. After cooling to room temperature the solvent was removed in vacuo, the residue washed with hexanes and the solid/liquid mixture was filtered to yield 4.48g (71%) of solid product.

후처리

  1. customTo a 250ml round-bottom flask equipped with a magnetic stir-bar
  2. temperatureThe reaction mixture was refluxed overnight
  3. customwas removed in vacuo
  4. washthe residue washed with hexanes
  5. filtrationthe solid/liquid mixture was filtered

출처 및 근거

ORD 기록
ord-a8fd80fb3ecd46b39c18bdf4df3422d0
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449468B2

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