Propargyl bromide → 3-(Prop-2-ynyloxy)pyridine
반응식
[OH:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.C[O-].[Na+].[CH2:11](Br)[C:12]#[CH:13]>CN(C)C=O>[CH2:13]([O:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1)[C:12]#[CH:11]참가 물질
5
실험 절차
To a mixture of 9.5 g (0.1 mole) 3-hydroxypyridine, 5.2 g (0.1 mole) sodium methylate and 150 ml N,N-dimethylformamide, there was added 12.0 g (0.1 mole) propargyl bromide at room temperature over a two hour period. Most of the solvent was removed under reduced pressure. The residue was taken up with 200 ml methylene chloride and 100 ml water, the layers were separated and the methylene chloride evaporated to give 4.5 g 3-(2-propynyloxy)pyridine, yield 34%.
후처리
- customMost of the solvent was removed under reduced pressure
- customthe layers were separated
- customthe methylene chloride evaporated
출처 및 근거
- ORD 기록
- ord-6783eeea9c804d0b933662c82c1126bf
- 출처 데이터셋
- uspto-grants-1980_09
- 특허 번호
- US04220577
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