Azobisisobutyronitrile → 6-Bromo-2-(bromomethyl)quinoline
반응식
CC(N=NC(C#N)(C)C)(C#N)C.[Br:13]N1C(=O)CCC1=O.[Br:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[N:28]=[C:27]([CH3:32])[CH:26]=[CH:25]2>C(Cl)(Cl)(Cl)Cl>[Br:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[N:28]=[C:27]([CH2:32][Br:13])[CH:26]=[CH:25]2참가 물질
5
실험 절차
148 mg (1.00 mmol) α,α-azoisobutyronitrile and 8.01 g (45.0 mmol) N-bromosuccinimide are added successively to a solution of 10.0 g (45.0 mmol) 6-bromo-2-methyl-quinoline in 60 mL carbon tetrachloride. The reaction mixture is refluxed for 8 h. It is filtered and the filtrate is washed twice with water. The organic phase is dried over MgSO4 and the solvent is eliminated i.vac. The purification is carried out by column chromatography on silica gel (PE/EtOAc 4:1).
후처리
- temperatureThe reaction mixture is refluxed for 8 h
- filtrationIt is filtered
- washthe filtrate is washed twice with water
- dry with materialThe organic phase is dried over MgSO4
- customThe purification
출처 및 근거
- ORD 기록
- ord-db2786f5491b42db8a1a82a6a28f7cd1
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07452911B2
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