Benzyl Chloride → Benzyl Phenyl Ether

HRID 273662

반응식

HRID 273662 반응식
O.O.O.[C:4]1([O-:10])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[Na+].[CH2:12](Cl)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CO>[CH2:12]([O:10][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 7503Benzyl ChlorideHCID 23681143Sodium Phenoxide Trihydrate

생성물 1

HCID 70352Benzyl Phenyl Ether수율 67%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of sodium phenolate trihydrate (10.2 g; 60 mmole) and benzyl chloride (6.4 ml; 56 mmole) in methanol (150 ml) was pumped through the system (15 ml/minute; 146°-7° C.; 1000-1050 kPa). The MeOH was rotary evaporated off and the residue recrystallised from EtOH to afford colourless needles of phenyl benzyl ether (6.9 g; 67% yield), m.p. 36°-36.3° C.

후처리

  1. customwas pumped through the system (15 ml/minute; 146°-7° C.; 1000-1050 kPa)
  2. customThe MeOH was rotary evaporated off
  3. customthe residue recrystallised from EtOH

출처 및 근거

ORD 기록
ord-80ea20519fd44352987956fe78cc4b12
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05387397

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