Sodium Hydroxide → 4-Acetylamino-5-(3-methoxyphenyl)valeric acid

HRID 274076

반응식

HRID 274076 반응식
[C:1]([NH:4][CH:5]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=1)[CH2:6][CH2:7][C:8]([O:10]C(C)(C)C)=[O:9])(=[O:3])[CH3:2].[OH-].[Na+]>O1CCOCC1.Cl>[C:1]([NH:4][CH:5]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=1)[CH2:6][CH2:7][C:8]([OH:10])=[O:9])(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 20094840Tert-butyl 4-acetylamino-5-(3-methoxyphenyl)valerate

생성물 1

HCID 200947844-Acetylamino-5-(3-methoxyphenyl)valeric acid수율 86.3%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 312751,4-Dioxane용매2회

실험 절차

To a solution of tert-butyl 4-acetylamino-5-(3-methoxyphenyl)valerate (508 mg) in 1,4-dioxane (2 ml), 4N hydrogen chloride in 1,4-dioxane (4 ml) was added and the solution was stirred for 1 hour. The solution was poured into ice water (6 ml) and the pH of the solution was adjusted to 12 with sodium hydroxide solution. The solution was washed successively with diisopropyl ether and ethyl acetate and the pH of the solution was adjusted to 1 with 6N hydrochloric acid. The solution was extracted with ethyl acetate and the extract was washed with brine, dried over anhydrous sodium sulfate, and evaporated in vacuo to give 4-acetylamino-5-(3-methoxyphenyl)valeric acid (362 mg).

후처리

  1. washThe solution was washed successively with diisopropyl ether and ethyl acetate
  2. extractionThe solution was extracted with ethyl acetate
  3. washthe extract was washed with brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-6ed3ce07efd2419ca22ddb8ad687b278
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05387710

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