Hydrochloric Acid → HCID 20092143, 화합물

HRID 274186노트

반응식

HRID 274186 반응식
[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[C:18]([F:23])[N:17]=2)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Br[CH:25]([O:27][CH2:28][CH3:29])[CH3:26].[OH-].[Na+].Cl>O.C(O)C>[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:26][CH2:25][O:27][CH2:28][CH3:29])=[C:18]([F:23])[N:17]=2)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 145479151-Bromo-1-ethoxyethaneHCID 190469612-(4-Octyloxyphenyl)-5-hydroxy-6-fluoropyridine

생성물 1

HCID 20092143HCID 20092143, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A mixture of 0.1 mol of 2C, 0.1 mol of 1-bromoethoxyethane, 0.1 mol of sodium hydroxide, 20 ml of ethanol and 50 ml of water is heated at the boil for 2 hours. The mixture is cooled, dilute hydrochloric acid is added, and the aqueous phase is extracted with dichloromethane. The solvent is removed under reduced pressure, and the residue is purified by column chromatography, giving the product 2-(4-octyloxyphenyl)-5-(2-ethoxyethoxy)-6-fluoropyridine.

후처리

  1. temperatureis heated at the boil for 2 hours
  2. temperatureThe mixture is cooled
  3. extractionthe aqueous phase is extracted with dichloromethane
  4. customThe solvent is removed under reduced pressure
  5. customthe residue is purified by column chromatography

출처 및 근거

ORD 기록
ord-4e0bc83878c14500884c11b6594ab2ff
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05389291

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