4'-Chloropropiophenone → 2-Bromo-1-(4-chlorophenyl)propan-1-one

HRID 274341

반응식

HRID 274341 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:4][CH:3]=1.[Br:12]Br>C(Cl)(Cl)Cl.[Cl-].[Al+3].[Cl-].[Cl-]>[Br:12][CH:9]([CH3:10])[C:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)=[O:11]

참가 물질

5

반응물 2

HCID 226974'-ChloropropiophenoneHCID 24408Bromine

생성물 1

HCID 37882192-Bromo-1-(4-chlorophenyl)propan-1-one수율 100%

시약·촉매·용매 2

HCID 6451240Aluminum(III) Chloride촉매HCID 6212Chloroform용매

실험 절차

4'-chloropropiophenone (39.6 g) and anhydrous aluminum chlorid (0.1 g) were dissolved in 100 ml of chloroform. To the resulting solution was protionwise added bromine (37.6 g) at a temperature of 30° to 35° C. The reaction mixture was stirred at room temperature for 30 minutes. Then nitrogen was blown into the reaction mixture to remove the formed hydrogen bromide therefrom. Thereafter, the solvent was distilled off under reduced pressure to give 2-bromo-4'-chloropropiophenone (58.1 g). mp 77.5°-79.5° C.

후처리

  1. customat a temperature of 30° to 35° C
  2. customto remove the formed hydrogen bromide
  3. distillationThereafter, the solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-e7e3e66bcd3044e68b419873ba254cb4
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05389648

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