1-Hydroxy-2-naphthoic acid → 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid

HRID 274762

반응식

HRID 274762 반응식
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([OH:14])=[O:13].[Br:15]Br>C(Cl)(Cl)Cl>[Br:15][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([OH:1])=[C:3]([C:12]([OH:14])=[O:13])[CH:4]=1

참가 물질

4

반응물 2

HCID 68441-Hydroxy-2-naphthoic acidHCID 24408Bromine

생성물 1

HCID 2893934-Bromo-1-hydroxynaphthalene-2-carboxylic acid

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a suspension of 1-hydroxy-2-naphthoic acid (2.5 g; 13.3 mm) in chloroform (50 ml) was added bromine (0.68 ml) in chloroform (5 ml) dropwise and the reaction stirred at room temperature for one hour. The solvent was removed in vacuo, the solid washed repeatedly with water and collected by filtration and dried to give 4-bromo-1-hydroxy-naphthalene-2-carboxylic acid as a white solid.

후처리

  1. customThe solvent was removed in vacuo
  2. washthe solid washed repeatedly with water
  3. filtrationcollected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-657abbb53a14432ebc0bf161407cc8a6
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05389684

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