4-Pyridinecarboxylic acid, 1-oxide → 6,11-dihydro-11-(4-piperidinylidene)-5H-imidazo[2,1-b][3]benzazepine

HRID 275279

반응식

HRID 275279 반응식
Cl.CN(C)[CH2:4][CH2:5][CH2:6][N:7]=[C:8]=[N:9][CH2:10][CH3:11].[N+:13]1([O-])[CH:18]=[CH:17][C:16]([C:19](O)=O)=[CH:15][CH:14]=1.O.ON1[C:29]2[CH:30]=C[CH:32]=[CH:33][C:28]=2N=N1>>[NH:13]1[CH2:18][CH2:17][C:16](=[C:19]2[C:30]3[CH:29]=[CH:28][CH:33]=[CH:32][C:4]=3[CH2:5][CH2:6][N:7]3[CH:11]=[CH:10][N:9]=[C:8]23)[CH2:15][CH2:14]1

참가 물질

4

반응물 3

HCID 261304-Pyridinecarboxylic acid, 1-oxideHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27960291-Hydroxybenzotriazole hydrate

생성물 1

HCID 186124926,11-dihydro-11-(4-piperidinylidene)-5H-imidazo[2,1-b][3]benzazepine

실험 절차

6,11-dihydro-11-(4-piperidinylidene)-5H-imidazo[2,1-b][3]benzazepine (C) was prepared as described in Example 4. The Aldrich Chemical Company supplies 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, pyridine-4-carboxylic acid N-oxide, and 1-hydroxybenzotriazole hydrate.

출처 및 근거

ORD 기록
ord-ade618fc01a642c6b8c4f20c8512cbc5
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05393753

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