N-bromobutanimide → 4-Bromo-7-methoxy-3-methyl-2-trifluoromethylbenzimidazole

HRID 275794

반응식

HRID 275794 반응식
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([C:13]([F:16])([F:15])[F:14])[N:11]([CH3:12])[C:7]=2[CH:6]=[CH:5][CH:4]=1.[Br:17]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[Br:17][C:6]1[C:7]2[N:11]([CH3:12])[C:10]([C:13]([F:16])([F:14])[F:15])=[N:9][C:8]=2[C:3]([O:2][CH3:1])=[CH:4][CH:5]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 183166367-Methoxy-3-methyl-2-trifluoromethylbenzimidazole

생성물 1

HCID 183166224-Bromo-7-methoxy-3-methyl-2-trifluoromethylbenzimidazole수율 92%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a solution of 7-methoxy-3-methyl-2-trifluoromethylbenzimidazole (1.4 g) in chloroform (50 ml) under nitrogen was added N-bromosuccinimide (1.2 g). The mixture was stirred for 20 minutes before the reaction was quenched by the addition of 5% sodium metabisulphite solution (50 ml) and the organic layer was separated. Washing with water (50 ml), drying over anhydrous magnesium sulphate and removal of the solvent in vacuo gave an orange oil. Purification by flash chromatography eluting with 50% ethyl acetate in hexane gave the title compound as an orange solid (1.73 g).

후처리

  1. customwas quenched by the addition of 5% sodium metabisulphite solution (50 ml)
  2. customthe organic layer was separated
  3. washWashing with water (50 ml)
  4. dry with materialdrying over anhydrous magnesium sulphate and removal of the solvent in vacuo
  5. customgave an orange oil
  6. customPurification by flash chromatography
  7. washeluting with 50% ethyl acetate in hexane

출처 및 근거

ORD 기록
ord-de379988852f45a1b9e7d4a9df08a5f3
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353010B1

연결된 노트

불러오는 중…