2,5-Dimethylaniline → N-(2,5-Dimethylphenyl)acetamide

HRID 275994

반응식

HRID 275994 반응식
[CH3:1][C:2]1[CH:8]=[CH:7][C:6]([CH3:9])=[CH:5][C:3]=1[NH2:4].[C:10](OC(=O)C)(=[O:12])[CH3:11]>CN(C)C1C=CN=CC=1.ClCCl>[CH3:1][C:2]1[CH:8]=[CH:7][C:6]([CH3:9])=[CH:5][C:3]=1[NH:4][C:10](=[O:12])[CH3:11]

참가 물질

5

반응물 2

HCID 72592,5-DimethylanilineHCID 7918Acetic Anhydride

생성물 1

HCID 16304N-(2,5-Dimethylphenyl)acetamide

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 2,5-dimethylaniline (5.30 g) and 4-dimethylaminopyridine (6.41 g) in dichloromethane (90 ml) was added acetic anhydride (4.13 ml) under ice-cooling, and the mixture was stirred for 4 hours. The reaction mixture was washed with 1N hydrochloric acid and a saturated aqueous sodium bicarbonate solution subsequently, and dried over anhydrous magnesium sulfate. Removal of the solvent in vacuo gave 2′,5′-dimethylacetanilide (6.09 g).

후처리

  1. temperaturecooling
  2. washThe reaction mixture was washed with 1N hydrochloric acid
  3. dry with materiala saturated aqueous sodium bicarbonate solution subsequently, and dried over anhydrous magnesium sulfate
  4. customRemoval of the solvent in vacuo

출처 및 근거

ORD 기록
ord-e1d948e4bff14b87b806b0d181e33941
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353025B1

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