Thionyl Chloride → 1-(chloromethyl)-1-(cyclohexylamino)cyclopentane HCl salt

HRID 276265

반응식

HRID 276265 반응식
[CH:1]1([NH:7][C:8]2([CH2:13]O)[CH2:12][CH2:11][CH2:10][CH2:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O=S(Cl)[Cl:17]>Cl>[ClH:17].[Cl:17][CH2:13][C:8]1([NH:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[CH2:12][CH2:11][CH2:10][CH2:9]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 183161421-(Cyclohexylamino)-1-(hydroxymethyl)cyclopentane

생성물 1

HCID 699929051-(chloromethyl)-1-(cyclohexylamino)cyclopentane HCl salt수율 195.8%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
70 °C

실험 절차

A 4M HCl solution (p-dioxane, 40 mL) containing 1-(cyclohexylamino)-1-(hydroxymethyl)cyclopentane (Method B4a; 1.9 g, 9.6 mmol) and SOCl2 (0.84 mL, 11.5 mmol) was heated to 70° C. for 18 h. The resulting mixture was cooled to room temp. and concentrated under reduced pressure to yield crude 1-(chloromethyl)-1-(cyclohexylamino)cyclopentane HCl salt (2.84 g), which was used in the next step without firer purification.

후처리

  1. temperatureThe resulting mixture was cooled to room temp.
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-2c95e3be24164d069c9b63100bdf0900
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353006B1

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