Acetic Anhydride → 2-Acetamido-5-nitropyridine

HRID 276846

반응식

HRID 276846 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>N1C=CC=CC=1.CN(C)C1C=CN=CC=1>[C:11]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1)(=[O:13])[CH3:12]

참가 물질

5

반응물 2

HCID 7918Acetic AnhydrideHCID 778882-Amino-5-nitropyridine

생성물 1

HCID 3451252-Acetamido-5-nitropyridine

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 1049Pyridine용매

실험 절차

2-Amino-5-nitropyridine was treated with acetic anhydride in dry pyridine in the presence of 4-dimethylaminopyridine at room temperature for 24 hrs under argon. The solvent was removed by rotary evaporation. The residue was dissolved in CH2Cl2, and ether was added to form a solid. The white solid was collected and dried giving 2-acetamido-5-nitropyridine. Hydrogenation of this material using 10%Pd on C in MeOH at room temperature under atmospheric pressure gave 2-acetamido-5-aminopyridine.

후처리

  1. customThe solvent was removed by rotary evaporation
  2. dissolutionThe residue was dissolved in CH2Cl2
  3. additionether was added
  4. customto form a solid
  5. customThe white solid was collected
  6. customdried

출처 및 근거

ORD 기록
ord-0dc588cad01a499ab6e8b0dc91da72e7
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06355636B1

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