Hydrochloric Acid → 4-(Methanesulfonylmethyl)benzoic acid

HRID 277578노트

반응식

HRID 277578 반응식
[CH3:1][S:2]([CH2:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12]C)=[O:11])=[CH:8][CH:7]=1)(=[O:4])=[O:3].Cl>[OH-].[Na+]>[CH3:1][S:2]([CH2:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=1)(=[O:3])=[O:4]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 2804364Methyl 4-(methylsulfonylmethyl)benzoate

생성물 1

HCID 5060694-(Methanesulfonylmethyl)benzoic acid수율 100.8%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

반응 조건

온도
0 °C

실험 절차

A solution of commercially available methyl 4-(methanesulphonylmethyl)benzoate (1.00 g, 4.4 mmol) in 2M NaOH (25 mL) was heated at reflux for 30 minutes under N2. The reaction mixture was cooled to 0° C. and acidified with 2M HCl (15 mL) to a pH below 2. The white precipitate was filtered and dried to provide the title compound as a white solid (0.95 g, 97% yield): 1HNMR (DMSO-d6) δ2.97 (s, 3H), 4.61 (s, 2H), 7.49 (d, J=0.5 Hz, 2H), 7.94-7.98 (d, J=0.5 Hz, 2H), 13.00 (s, 1H): MS (ESI) [M−H]− at m/z 213.

후처리

  1. temperatureat reflux for 30 minutes under N2
  2. filtrationThe white precipitate was filtered
  3. customdried

출처 및 근거

ORD 기록
ord-707bf3a60b254a74ab61480452a90733
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06355633B1

반응 노트

불러오는 중…