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Hydrochloric Acid → 8-Hydroxy-3,7-dimethyl-octa-2,4,6-trien-1-oic acid ethyl ester

HRID 27867
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인쇄 미리보기

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HRID 27867 반응식
[CH2:1]([O:3][C:4](=[O:15])[CH:5]=[C:6]([CH3:14])[CH:7]=[CH:8][CH:9]=[C:10]([CH:12]=[O:13])[CH3:11])[CH3:2].[BH4-].[Na+].Cl>C(O)C>[CH2:1]([O:3][C:4](=[O:15])[CH:5]=[C:6]([CH3:14])[CH:7]=[CH:8][CH:9]=[C:10]([CH3:11])[CH2:12][OH:13])[CH3:2]
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참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 54295620Ethyl 3,7-dimethyl-8-oxoocta-2,4,6-trienoate

생성물 1

HCID 539260748-Hydroxy-3,7-dimethyl-octa-2,4,6-trien-1-oic acid ethyl ester

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
10 °C

실험 절차

36 g. of 7-formyl-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester are dissolved in 600 ml. of absolute ethanol. The solution is treated portionwise with 1.8 g. of sodium borohydride. The mixture is stirred for 2 hours at 10° C., then poured onto ice water and 3 n aqueous hydrochloric acid and extracted with ether. The ether extract is washed successively with water, a saturated aqueous sodium bicarbonate sodium and once more with water, dried over sodium sulfate and evaporated. There is obtained 8-hydroxy-3,7-dimethyl-octa-2,4,6-trien-1-oic acid ethyl ester, which is processed further as follows:

후처리

  1. additionThe solution is treated portionwise with 1.8 g
  2. extractionextracted with ether
  3. extractionThe ether extract
  4. washis washed successively with water
  5. dry with materiala saturated aqueous sodium bicarbonate sodium and once more with water, dried over sodium sulfate
  6. customevaporated

출처 및 근거

ORD 기록
ord-cc9bee96907546cab6b85a562360d591
출처 데이터셋
uspto-grants-1980_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04224244

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