Sodium Hydroxide → 2-[4-(4-Carboxymethylphenyl)-3-cyclohexen-1-yl]propyl 2-propanesulfonamide

HRID 279359노트

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HRID 279359 반응식
[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH2:15][CH2:14][CH:13]([CH:16]([CH3:25])[CH2:17][CH2:18][CH:19]([S:21]([NH2:24])(=[O:23])=[O:22])[CH3:20])[CH2:12][CH:11]=2)=[CH:6][CH:5]=1)#N.[OH-:26].[Na+].S(=O)(=O)(O)[O-:29].[Na+]>O1CCOCC1>[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH2:15][CH2:14][CH:13]([CH:16]([CH3:25])[CH2:17][CH2:18][CH:19]([S:21]([NH2:24])(=[O:23])=[O:22])[CH3:20])[CH2:12][CH:11]=2)=[CH:6][CH:5]=1)([OH:29])=[O:26]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 516919Sodium BisulfateHCID 867579052-[4-(4-Cyanomethylphenyl)-3-cyclohexen-1-yl]propyl 2-propanesulfonamide

생성물 1

HCID 867562312-[4-(4-Carboxymethylphenyl)-3-cyclohexen-1-yl]propyl 2-propanesulfonamide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
100 °C

실험 절차

To a solution of N-[2-[4-(4-cyanomethylphenyl)-3-cyclohexen-1-yl]propyl 2-propanesulfonamide (see Example 15) in dioxane is added 5 N sodium hydroxide. The mixture is heated to 100° C. for 24 hr. The mixture is then cooled, and acidified with 10% aqueous sodium bisulfate. The mixture is extracted three times with ethyl acetate and the combined organic extracts are dried, filtered and concentrated in vacuo to afford the title compound.

후처리

  1. temperatureThe mixture is then cooled
  2. extractionThe mixture is extracted three times with ethyl acetate
  3. customthe combined organic extracts are dried
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-c492a67587874836829d7f95f2992b0d
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362230B1

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