Propionic Acid → 1-(2-Ethyl-4-methyloxazol-5-yl)ethanone

반응식

Cl[CH:2]([C:6](=[O:8])[CH3:7])[C:3](=O)[CH3:4].[C:9]([NH2:13])(=[O:12])[CH2:10][CH3:11].C(O)(=O)CC.[OH-].[Na+]>>[C:6]([C:2]1[O:12][C:9]([CH2:10][CH3:11])=[N:13][C:3]=1[CH3:4])(=[O:8])[CH3:7]

참가 물질

반응물 4

HCID 1032Propionic Acid

HCID 6578Propionamide

HCID 14798Sodium Hydroxide

HCID 743283-Chloro-2,4-pentanedione

생성물 1

HCID 189363281-(2-Ethyl-4-methyloxazol-5-yl)ethanone

실험 절차

3-Chloropentane-2,4-dione (46.5 g), propionamide (50 g) and propionic acid (151 g) were heated at 145° C. for 5 hours. The mixture was cooled to room temperature, then basified to pH 10 using 10M aqueous sodium hydroxide, and extracted with dichloromethane. The combined extracts were washed with brine, dried and the solvent removed to leave a brown oil which was purified by vacuum distillation, b.p. 70° C. at 2 mbar.