Propionic Acid → 1-(2-Ethyl-4-methyloxazol-5-yl)ethanone

HRID 2796

반응식

HRID 2796 반응식
Cl[CH:2]([C:6](=[O:8])[CH3:7])[C:3](=O)[CH3:4].[C:9]([NH2:13])(=[O:12])[CH2:10][CH3:11].C(O)(=O)CC.[OH-].[Na+]>>[C:6]([C:2]1[O:12][C:9]([CH2:10][CH3:11])=[N:13][C:3]=1[CH3:4])(=[O:8])[CH3:7]

참가 물질

5

반응물 4

HCID 1032Propionic AcidHCID 6578PropionamideHCID 14798Sodium HydroxideHCID 743283-Chloro-2,4-pentanedione

생성물 1

HCID 189363281-(2-Ethyl-4-methyloxazol-5-yl)ethanone

실험 절차

3-Chloropentane-2,4-dione (46.5 g), propionamide (50 g) and propionic acid (151 g) were heated at 145° C. for 5 hours. The mixture was cooled to room temperature, then basified to pH 10 using 10M aqueous sodium hydroxide, and extracted with dichloromethane. The combined extracts were washed with brine, dried and the solvent removed to leave a brown oil which was purified by vacuum distillation, b.p. 70° C. at 2 mbar.

후처리

  1. extractionextracted with dichloromethane
  2. washThe combined extracts were washed with brine
  3. customdried
  4. customthe solvent removed
  5. customto leave a brown oil which
  6. distillationwas purified by vacuum distillation, b.p. 70° C. at 2 mbar

출처 및 근거

ORD 기록
ord-eb5bfefcbfd94ea0be77c604cb53b9bd
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731335

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