Succinic anhydride → Thyroxine

HRID 279819

반응식

HRID 279819 반응식
O1CCCC1.C(N(CC)CC)C.C1(=O)OC(=O)CC1.Cl.C[O:22][C:23](=[O:45])[C@H:24]([CH2:26][C:27]1[CH:34]=[C:32]([I:33])[C:31]([O:35][C:36]2[CH:43]=[C:41]([I:42])[C:40]([OH:44])=[C:38]([I:39])[CH:37]=2)=[C:29]([I:30])[CH:28]=1)[NH2:25]>>[NH2:25][C@H:24]([C:23]([OH:45])=[O:22])[CH2:26][C:27]1[CH:28]=[C:29]([I:30])[C:31]([O:35][C:36]2[CH:37]=[C:38]([I:39])[C:40]([OH:44])=[C:41]([I:42])[CH:43]=2)=[C:32]([I:33])[CH:34]=1

참가 물질

5

반응물 4

HCID 7922Succinic anhydrideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 13911220Methyl thyroxinate hydrochloride

생성물 1

HCID 5819Thyroxine

반응 조건

온도
4 °C

실험 절차

In 150 ml of dried tetrahydrofuran 1.65 g (0.002 mol) of thyroxine methyl ester hydrochloride was dissolved. To the resulting solution 300 μl (0.0021 mol) of triethyl amine and 200 mg. (0.0022 mol) of succinic anhydride were added. The mixture was stirred at 4° C. overnight to effect reaction.

후처리

  1. customreaction

출처 및 근거

ORD 기록
ord-d6e33fbb8e70494a89adc8bd3b8100b1
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04587102

연결된 노트

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