Acetic Anhydride → Methylprednisolone Aceponate

HRID 279827

반응식

HRID 279827 반응식
[OH:1][C@H:2]1[CH2:22][C@@:21]2([CH3:23])[C@@H:13]([CH2:14][CH2:15][C@:16]2([O:24][C:25](=[O:28])[CH2:26][CH3:27])[C:17](=[O:20])[CH2:18][OH:19])[C@H:12]2[C@H:3]1[C@:4]1([CH3:31])[C:9]([C@@H:10]([CH3:29])[CH2:11]2)=[CH:8][C:7](=[O:30])[CH:6]=[CH:5]1.[C:32](OC(=O)C)(=[O:34])[CH3:33]>N1C=CC=CC=1>[C:32]([O:19][CH2:18][C:17](=[O:20])[C@:16]1([O:24][C:25](=[O:28])[CH2:26][CH3:27])[C@:21]2([CH3:23])[C@H:13]([C@H:12]3[C@H:3]([C@@H:2]([OH:1])[CH2:22]2)[C@:4]2([CH3:31])[C:9](=[CH:8][C:7](=[O:30])[CH:6]=[CH:5]2)[C@@H:10]([CH3:29])[CH2:11]3)[CH2:14][CH2:15]1)(=[O:34])[CH3:33]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 10025718Methylprednisolone 17-Propionate

생성물 1

HCID 63019Methylprednisolone Aceponate

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Analogously to Example 1, 1.0 g of 11β,21-dihydroxy-6α-methyl-17-propionyloxy-1,4-pregnadiene-3,20-dione is stirred in 10 ml of pyridine with 5 ml of acetic anhydride for one hour at room temperature and then worked up, thus isolating 790 mg of 21-acetoxy-11β-hydroxy-6α-methyl-17-propionyloxy-1,4-pregnadiene-3,20-dione, mp 138° C.

출처 및 근거

ORD 기록
ord-759df690686e4bae8fe7d3dd8ac9ca11
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04587236

연결된 노트

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