Hydrochloric Acid → HCID 14631382, 화합물
반응식
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH:6](O)[CH3:7].[CH2:9]=[O:10].[Cl-:11].[Ca+2].[Cl-].Cl>C(Cl)Cl>[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][O:10][CH2:9][Cl:11]참가 물질
6
반응 조건
- 온도
- -5 °C
실험 절차
Hydrogen chloride gas was bubbled into a mixture containing 24 g (200 mmol) of (2-methoxyethoxy)ethanol, 6.0 g (200 mmol) of paraformaldehyde and 22 g (200 mmol) of powdered calcium chloride with stirring and cooling to -5° C. The HCl was continued for 4 hours as the temperature was allowed to rise gradually to 8° C. Celite was added and the reaction filtered. The filtrate was evaporated leaving 29.8 g of a cloudy oil. The oil was dissolved in methylene chloride and dried over molecular sieves. Evaporation furnished 19.3 g of [2-(2-methoxyethoxy)ethoxy]methyl chloride as an oil which was characterized by nuclear magnetic resonance.
후처리
- customHydrogen chloride gas was bubbled into a mixture
- customto rise gradually to 8° C
- additionCelite was added
- filtrationthe reaction filtered
- customThe filtrate was evaporated
- customleaving 29.8 g of a cloudy oil
- customdried over molecular sieves
- customEvaporation
출처 및 근거
- ORD 기록
- ord-f6bf9af3c37e4176ac961fcb590948dc
- 출처 데이터셋
- uspto-grants-1986_05
- 특허 번호
- US04587247
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