1,1,1-Trifluoro-2,4-pentanedione → 1-(2-Amino-4-(trifluoromethyl)thiazol-5-yl)ethanone

HRID 2801

반응식

HRID 2801 반응식
OC1C(OS(C2C=CC(C)=CC=2)(=O)=O)=C(I)C=CC=1.[F:20][C:21]([F:29])([F:28])[C:22](=O)[CH2:23][C:24](=[O:26])[CH3:25].[NH2:30][C:31]([NH2:33])=[S:32]>C(#N)C>[C:24]([C:23]1[S:32][C:31]([NH2:33])=[N:30][C:22]=1[C:21]([F:29])([F:28])[F:20])(=[O:26])[CH3:25]

참가 물질

5

반응물 3

HCID 739431,1,1-Trifluoro-2,4-pentanedioneHCID 2723790ThioureaHCID 21918218Hydroxy tosyloxy iodobenzene

생성물 1

HCID 189363001-(2-Amino-4-(trifluoromethyl)thiazol-5-yl)ethanone

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Hydroxy(tosyloxy)iodobenzene (78.5 g) was added to a solution of 1,1,1-trifluoropentane-2,4-dione in acetonitrile (500 ml). The mixture was heated under reflux for 45 minutes, then cooled, and thiourea (15.2 g) was added. The mixture was heated under reflux for 4 hours and then left to stand overnight. Evaporation and crystallisation of the residue from dichloromethane gave the title compound.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 45 minutes
  3. temperaturecooled
  4. temperatureThe mixture was heated
  5. temperatureunder reflux for 4 hours
  6. waitleft
  7. customEvaporation and crystallisation of the residue from dichloromethane

출처 및 근거

ORD 기록
ord-ea8d9c1fc5de4b569364ab4d8c41abcc
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731335

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