Methyl iodide → 4-Bromo-1,3,5-trimethylpyrazole

HRID 2802

반응식

HRID 2802 반응식
[Br:1][C:2]1[C:3]([CH3:8])=[N:4][NH:5][C:6]=1[CH3:7].[H-].[Na+].[H][H].IC.[C:15](=O)([O-])O.[Na+]>CN(C)C=O>[Br:1][C:2]1[C:3]([CH3:8])=[N:4][N:5]([CH3:15])[C:6]=1[CH3:7]

참가 물질

7

반응물 5

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 769374-bromo-3,5-dimethyl-1H-pyrazoleHCID 516892Sodium BicarbonateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 5191814-Bromo-1,3,5-trimethylpyrazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

4-Bromo-3,5-dimethylpyrazole (10 g) in dry dimethylformamide (50 ml) was added to a stirred suspension of sodium hydride (1.8 g) in dry dimethylformamide at 0° C. When the evolution of hydrogen was complete, iodomethane (8.9 g) was added dropwise. The mixture was allowed to warm to room temperature and after 30 minutes saturated aqueous sodium hydrogen carbonate (5 ml) was added. Following evaporation under high vacuum, the residue was purified by column chromatography to give the title compound.

후처리

  1. additionwas added
  2. customevaporation under high vacuum
  3. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-ac7f5eb35ef547d1a557dea38319f19e
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731335

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